- Sand Gravel & Aggregate, Rogersville
- Sandwich Shop Restaurants, Rogersville
- Savings Banks, Rogersville
- Scrap & Waste Materials, Rogersville
- Screen Printing, Rogersville
- Search & Rescue, Rogersville
- Secondary Schools, Rogersville
- Security Brokers & Dealers, Rogersville
- Senior Citizens Service & Health Organizations, Rogersville
- Septic Tanks & Septic Systems Contractors, Rogersville - Installation, Repair, Service, Cleaning & Pumping Septic Tanks
- Sewing & Yarn Stores & Supplies, Rogersville
- Sheriff's Department, Rogersville
- Shoe Stores, Rogersville - Mens, Womens & Kids Shoes
- Shopping & Shopping Services, Rogersville
- Signs, Rogersville
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- Skin Care & Cosmetology Salons, Rogersville
- Social Clubs & Organizations, Rogersville
- Social Security Counselors & Representatives, Rogersville
- Social Services & Welfare, Rogersville
- Societies & Foundation Associations, Rogersville
- Special Dies Tools Jigs & Fixtures Manufacturers, Rogersville
- Specialty Animal Services, Rogersville
- Specialty Stores, Rogersville
- Staffing & Support Services, Rogersville
- State Government, Rogersville
- Steak House Restaurants, Rogersville
- Stocks & Bond Brokers, Rogersville
- Surveyor Services, Rogersville - Surveying Service
- Surveyors, Rogersville
- Swimming Pools, Rogersville
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