- Sandwich Shop Restaurants, Erwin
- Scrap & Waste Materials, Erwin
- Screen Houses, Erwin
- Seafood Restaurants, Erwin
- Sealcoating, Erwin - Asphalt Sealcoating & Paving
- Secondary Schools, Erwin
- Security Brokers & Dealers, Erwin
- Security Investigative Services, Erwin
- Security Services, Erwin
- Senior Citizens Service & Health Organizations, Erwin
- Septic Tank Pumping & Cleaning, Erwin - Septic Systems
- Septic Tanks & Septic Systems Contractors, Erwin - Installation, Repair, Service, Cleaning & Pumping Septic Tanks
- Sewing & Yarn Stores & Supplies, Erwin
- Shopping & Shopping Services, Erwin
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- Siding Contractors, Erwin - Vinyl Siding, Wood, Metal & Aluminum Siding Contractors - Installation & Repair
- Signs, Erwin
- Social Services & Welfare, Erwin
- Societies & Foundation Associations, Erwin
- Special Dies Tools Jigs & Fixtures Manufacturers, Erwin
- Specialty Goods Storage, Erwin
- Specialty Stores, Erwin
- Stadiums, Arenas, Coliseums & Athletic Fields, Erwin
- State Government, Erwin
- Stock & Bond Brokers & Dealers, Erwin
- Stocks & Bond Brokers, Erwin
- Sunrooms & Solarium Construction Contractors, Erwin - Build & Repair
- Sunrooms, Greenhouses, Solariums & Atrium Builders, Erwin - Build & Repair
- Surveyor Services, Erwin - Surveying Service
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