- Sandwich Shop Restaurants, Lexington
- Satellite Dish Antennas & Equipment Dealers, Lexington
- Satellite TV Service, Lexington
- Scrap & Waste Materials, Lexington
- Screen Printing, Lexington
- Secondary Schools, Lexington
- Security & Surveillance System & Equipment, Lexington
- Security Brokers & Dealers, Lexington
- Senior Citizens Service & Health Organizations, Lexington
- Sewer & Drain Cleaning & Repair, Lexington - Drain Cleaner & Installation Services
- Sheet Metal Contractors, Lexington - Sheet Metal Fabrication
- Sheet Metal Fabricators & Ductwork Contractors, Lexington
- Sheriff's Department, Lexington
- Shoe Dyers, Lexington
- Shoe Repair Shops, Lexington
- Shoe Store - More, Lexington
- Shoe Stores, Lexington - Mens, Womens & Kids Shoes
- Shopping & Shopping Services, Lexington
- Siding Contractors, Lexington - Vinyl Siding, Wood, Metal & Aluminum Siding Contractors - Installation & Repair
- Siding Materials, Lexington
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- Signs, Lexington
- Small Appliances, Lexington
- Social Security And Disability Attorneys & Lawyers, Lexington
- Social Security And Disability Lawyers & Attorneys, Lexington
- Social Services & Welfare, Lexington
- Soil Preparation Services, Lexington
- Soil Solidification Services, Lexington
- Special Education & Care, Lexington
- Specialty Animal Services, Lexington
- Specialty Stores, Lexington
- Sporting Goods Stores, Lexington
- Sports Medicine, Lexington - Doctors, Physicians & Surgeons
- Spraying Booths & Equipment, Lexington
- Staffing & Support Services, Lexington
- State Government, Lexington
- Stocks & Bond Brokers, Lexington
- Substance Abuse Clinics, Lexington - Alcoholism, Addiction & Drug Abuse Treatment Centers
- Surveyor Services, Lexington - Surveying Service
- Swimwear & Accessories Shops, Lexington - Water Sports Equipment
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