- Sand Gravel & Aggregate, Savannah
- Sandwich Shop Restaurants, Savannah
- Satellite Dish Antennas & Equipment Dealers, Savannah
- Satellite TV Service, Savannah
- Sawmill & Planing Mills, Savannah
- Sawmill Supplies & Equipment Repair, Savannah
- Seafood Restaurants, Savannah
- Secondary Schools, Savannah
- Security & Surveillance System & Equipment, Savannah
- Security Brokers & Dealers, Savannah
- Senior Citizens Service & Health Organizations, Savannah
- Septic Tank Pumping & Cleaning, Savannah - Septic Systems
- Septic Tanks & Septic Systems Contractors, Savannah - Installation, Repair, Service, Cleaning & Pumping Septic Tanks
- Septic Tanks & Systems, Savannah - Wholesale, Dealers & Suppliers
- Sewing Machine Repair & Service, Savannah
- Shoe Repair Shops, Savannah
- Shoe Stores, Savannah - Mens, Womens & Kids Shoes
- Shopping & Shopping Services, Savannah
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- Skating Rink & Hockey Operation Services, Savannah
- Snacks & Desserts, Savannah
- Social Services & Welfare, Savannah
- Special Dies Tools Jigs & Fixtures Manufacturers, Savannah
- Special Education & Care, Savannah
- Special Events & Party Supply Rental, Savannah
- Speciality Food Stores, Savannah
- Specialty Animal Services, Savannah
- Specialty Goods Storage, Savannah
- Specialty Stores, Savannah
- Sporting Goods Stores, Savannah
- State Government, Savannah
- Steak House Restaurants, Savannah
- Stock & Bond Brokers & Dealers, Savannah
- Stock Yards, Savannah
- Stocks & Bond Brokers, Savannah
- Substance Abuse Clinics, Savannah - Alcoholism, Addiction & Drug Abuse Treatment Centers
- Surveyor Services, Savannah - Surveying Service
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